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Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture

机译：对非核苷类逆转录酶抑制剂具有抗性的人类免疫缺陷病毒1型（HIV-1）逆转录酶突变体表明，与细胞培养中的HIV-1复制适应性相关的RNase H切割率有所改变。

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Richard H. Archer; Carrie Dykes; Peter Gerondelis; Philip Fay; Richard C. Reichman; Robert A. Bambara; Lisa M. Demeter; Amanda Lloyd;
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1. The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys,3) that correlate with reductions in replication efficiency [J] . Wang J., Dykes C., Domaoal R. A., Virology . 2006,第2期

机译：HIV-1逆转录酶突变体G190S和G190A赋予了非核苷逆转录酶抑制剂的抗性，证明RNase H活性的降低和tRNA（Lys，3）的DNA合成与复制效率的降低相关
2. Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74 - Val or Ile and Val-7 [J] . Jorg-Peter Kleim, Manfred Rosner, Irvin Winkler Proceedings of the National Academy of Sciences of the United States of America . 1996,第1期

机译：1型人类免疫缺陷病毒（HIV-1）逆转录酶（RT）喹喔啉非核苷抑制剂对HIV-1复制的选择性压力导致出现核苷RT抑制剂特异性（RT Leu-74-Val或Ile和Val -7
3. The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in repl [J] . Wang J, Dykes C, Domaoal RA, Virology . 2006,第2期

机译：HIV-1逆转录酶突变体G190S和G190A赋予了对非核苷逆转录酶抑制剂的抗性，证明RNase H活性的降低和tRNA的DNA合成（Lys，3）与repl的降低有关
4. A Novel Detection of Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) for HIV-1 with AlGaN/GaN High Electron Mobility Transistors [C] . Yen-Wen Kang, Geng-Yen Lee, Jen-Inn Chyi, Symposium on wide bandgap semiconductor materials and devices;Meeting of the Electrochemical Society . 2013

机译：AlGaN / GaN高电子迁移率晶体管对HIV-1的非核苷逆转录酶抑制剂（NNRTIs）的新型检测
5. The effects of nonnucleoside reverse transcriptase inhibitor resistance mutations on human immunodeficiency virus type 1 replication and reverse transcriptase function. [D] . Gerondelis, Peter. 2001

机译：非核苷类逆转录酶抑制剂耐药性突变对人免疫缺陷病毒1型复制和逆转录酶功能的影响。
6. Mutants of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Demonstrate Altered Rates of RNase H Cleavage That Correlate with HIV-1 Replication Fitness in Cell Culture [O] . Richard H. Archer, Carrie Dykes, Peter Gerondelis, 2000

机译：抵抗非核苷逆转录酶抑制剂的人类免疫缺陷病毒1型（HIV-1）逆转录酶突变体表明与细胞培养中HIV-1复制适应性相关的RNase H裂解率发生了变化。
7. Mutants of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Demonstrate Altered Rates of RNase H Cleavage That Correlate with HIV-1 Replication Fitness in Cell Culture [O] . Archer, Richard H., Dykes, Carrie, Gerondelis, Peter, 2000

机译：抗非核苷类逆转录酶抑制剂的人类免疫缺陷病毒1型（HIV-1）逆转录酶突变体显示与细胞培养中HIV-1复制适应性相关的RNase H裂解率发生变化。

Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture

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